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| 产品货号： | E-AB-F1024H |
|---|---|
| 英文名称： | PE/Cyanine7 Anti-Mouse CD272/BTLA Antibody[PK18.6] |
| 产品分类： | 流式抗体 |
| 说明书（链接）： | https://789.bio/ea/5OWrjT |
| Reactivity： | Mouse |
| Isotype： | Rat IgG1, κ |
| Clonality： | Monoclonal |
| Abbre： | CD272;BTLA |
| Swissprot： | Q7TSA3 | Links: https://www.uniprot.org/uniprot/Q7TSA3 |
| Cellular Localization： | Membrane |
| Concentration： | 5 μL/Test |
| Storage： | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| CloneNo： | PK18.6 |
| Conjugation： | PE/Cyanine 7 |
| Background： | CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Form： | Liquid |
| Conjugation Information： | PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter). |
| Spectrum： | |
| Storage Buffer： | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Expiration Date： | 12个月 |
| Shipping： | 冰袋 |
| Host： | Rat |
| Isotype Control： | PE/Cyanine7 Rat IgG1, κ Isotype Control[HRPN] | Links: /p-pe_cyanine7_rat_igg1_isotype_control_hrpn-e_ab_f09822h |
| Gene ID： | 208154 | Links: https://www.ncbi.nlm.nih.gov/gene/208154 |
| Alternate Names： | B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, Btla, CD272 |
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