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| 产品货号： | AN004820P |
|---|---|
| 英文名称： | Purified Anti-Mouse TCR V beta8.1/2 Antibody[KJ16-133.18] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/h1OO8C |
| Reactivity： | Mouse |
| Isotype： | Rat IgG2a, κ |
| Verified Samples： | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Dilution： | FCM 2 μg/mL(1×10^5-5×10^5 cells) |
| Clonality： | Monoclonal |
| Immunogen： | Recombinant Mouse TCR V beta8.1/2 protein |
| Abbre： | TCR V beta8.1/2 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Purification Method： | >98%, Protein A/G purified |
| CloneNo： | KJ16-133.18 |
| Conjugation： | Unconjugated |
| Background： | The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Expiration Date： | 12个月 |
| Shipping： | Order now, ship in 3 days |
| Host： | Rat |
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