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| 产品货号： | E-AB-F1131A |
|---|---|
| 英文名称： | Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/tW5OCR |
| Reactivity： | Mouse |
| Isotype： | Rat IgG2a, κ |
| Clonality： | Monoclonal |
| Abbre： | CD279/PD-1 |
| Swissprot： | Q02242 | Links: https://www.uniprot.org/uniprot/Q02242 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Research Areas： | Cancer Biomarkers; Immunology; Inhibitory Molecules |
| CloneNo： | 29F.1A12 |
| Conjugation： | Unconjugated |
| Background： | CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Expiration Date： | 12个月 |
| Shipping： | Ice bag |
| Host： | Rat |
| Alternate Names： | Programmed Death-1, PD-1 |
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