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| 产品货号： | E-AB-F1107A |
|---|---|
| 英文名称： | Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/aeyu1K |
| Reactivity： | Mouse |
| Isotype： | Rat IgG2a, κ |
| Clonality： | Monoclonal |
| Abbre： | CD115/CSF-1R |
| Swissprot： | P09581 | Links: https://www.uniprot.org/uniprot/P09581 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Research Areas： | Immunology |
| CloneNo： | AFS98 |
| Conjugation： | Unconjugated |
| Background： | CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product’s natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Expiration Date： | 12个月 |
| Shipping： | Ice bag |
| Host： | Rat |
| Alternate Names： | CD115, CSF-1 receptor (EC:2.7.10.1), CSF-1-R, CSF-1R, Csf1r, Csfmr, Fms, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, Proto-oncogene c-Fms |
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