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| 产品货号： | AN002910P |
|---|---|
| 英文名称： | Purified Anti-Human HLA-G Antibody[87G] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/Ze5Z1K |
| Reactivity： | Human |
| Isotype： | Mouse IgG2a, κ |
| Verified Samples： | Verified Samples in FCM: JEG3 |
| Dilution： | FCM 2 μg/mL(1×10^5-5×10^5 cells) |
| Clonality： | Monoclonal |
| Immunogen： | Recombinant Human HLA-G protein |
| Abbre： | HLA-G |
| Swissprot： | P17693 | Links: https://www.uniprot.org/uniprot/P17693 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Purification Method： | >98%, Protein A/G purified |
| Research Areas： | Immunology |
| CloneNo： | 87G |
| Conjugation： | Unconjugated |
| Background： | HLA-G Antibody (4H84) is an IgG1 κ mouse monoclonal HLA-G antibody (also designated HLA major histocompatibility complex, class I, G antibody, human leukocyte antigen (HLA) G antibody, 45 kDa transmembrane class I human leukocyte antigen G antibody, chromosome 6p22 gene complex class 1G antibody, placenta trophoblast marker antibody, or fetal derived placental cell marker antibody) that detects the HLA-G protein of mouse, rat and human origin by WB, IP, IF and IHC(P). HLA-G Antibody (4H84) is available as both the non-conjugated anti-HLA-G antibody form, as well as multiple conjugated forms of anti-HLA-G antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor®conjugates. Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain, and a non-covalently associated protein, β-2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Expiration Date： | 12个月 |
| Shipping： | Ice bag |
| Host： | Mouse |
| Alternate Names： | HLA, MHC-G, HLA-G, HLA-G HLA-6.0 HLAG, HLA-G5, HLA-6.0, HLAG, alpha chain G, B2 microglobulin, class I, DADB-15K14.8, HLA 6.0, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen alpha chain G, HLA class I molecule, HLA G, HLA G antigen, HLA G histocompatibility antigen class I G, HLA G3, HLA60, HLA-G histocompatibility antigen, Major histocompatibility complex class I G, MHC class I antigen, MHC class I antigen G, MHC G, TCA, T-cell A locus |
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