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| 产品货号： | E-AB-F1110A |
|---|---|
| 英文名称： | Purified Anti-Human CD8a Antibody[OKT-8] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/W5hue5 |
| Reactivity： | Human |
| Isotype： | Mouse IgG2a, κ |
| Verified Samples： | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution： | FCM 2 μg/mL(1×10^5-5×10^5 cells) |
| Clonality： | Monoclonal |
| Immunogen： | Recombinant Human CD8 protein |
| Abbre： | CD8 |
| Swissprot： | P01732 | Links: https://www.uniprot.org/uniprot/P01732 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Purification Method： | >98%, Protein A/G purified |
| Research Areas： | Immunology |
| CloneNo： | OKT-8 |
| Conjugation： | Unconjugated |
| Background： | CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Expiration Date： | 12个月 |
| Shipping： | Ice bag |
| Host： | Mouse |
| Alternate Names： | CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2 |
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