| Background： |
CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability, cyclic ADP-ribose, NAADP+, and ADP-ribose . CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells . Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells. |
| Alternate Names： |
cADPr hydrolase, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, Acute lymphoblastic leukemia cells antigen CD, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, CD38, ADPRC 1, ADPRC1, Acute lymphoblastic leukemia cells antigen CD38, ADP ribosyl cyclase, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, CD38 antigen, CD38 molecule, CD38H, Cyclic ADP ribose hydrolase, EC 3.2.2.5, I-19, NIMR5 antigen, p45, ADP-ribosyl, T10, cyclase, 2′-phospho-ADP-ribosyl cyclase, 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase, 2′-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1 (ADPRC 1), Cyclic ADP-ribose hydrolase 1 (cADPr hydrolase 1), cyclic ADP-ribose hydrolase 1, ADP-ribosyl cyclase, ADP ribosyl cyclase, ADPRC1, CD38 antigen, CD38 molecule, CD38H, Cyclic ADP ribose hydrolase, EC 3.2.2.5, I-19, NIMR5 antigen, p45, T10, Acute lymphoblastic leukemia cells antigen CD38, ADP ribosyl cyclase, ADPRC1, CD38 antigen, CD38 molecule, CD38H, Cyclic ADP ribose hydrolase, EC 3.2.2.5, I-19, NIMR5 antigen, p45, T10, ADP ribosyl cyclase 1, ADP ribosyl cyclase/cyclic ADP-ribose hydrolase, CD 38, CD38 antigen (p45), Cd38-rs1, Cyclic ADP ribose hydrolase 1, Ecto nicotinamide adenine dinucleotide glycohydrolase, I19 (mouse), Lymphocyte differentiation antigen CD38, NAD(+) nucleosidase, NIM-R5 antigen, NIMR5 antigen (mouse), OTTHUMP00000158633, OTTHUMP00000217743 |
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