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| 产品货号： | E-AB-F1133A |
|---|---|
| 英文名称： | Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/t5dq9O |
| Reactivity： | Human |
| Isotype： | Mouse IgG2b, κ |
| Verified Samples： | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution： | FCM 2 μg/mL(1×10^5-5×10^5 cells) |
| Clonality： | Monoclonal |
| Immunogen： | Recombinant Human PD-L1 protein |
| Abbre： | PD-L1 |
| Swissprot： | Q9NZQ7 | Links: https://www.uniprot.org/uniprot/Q9NZQ7 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Purification Method： | >98%, Protein A/G purified |
| Research Areas： | Cancer Biomarkers; Costimulatory Molecules; Immunology |
| CloneNo： | 29E.2A3 |
| Conjugation： | Unconjugated |
| Background： | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Expiration Date： | 12个月 |
| Shipping： | Ice bag |
| Host： | Mouse |
| Alternate Names： | B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, B7-H, B7-H1, Programmed cell death ligand 1 |
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