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| 产品货号： | E-AB-F1144I |
|---|---|
| 英文名称： | PE/Cyanine5.5 Anti-Human CD49d Antibody[9F10] |
| 产品分类： | 流式抗体 |
| 说明书（链接）： | https://789.bio/ea/5Wv9uH |
| Reactivity： | Human |
| Isotype： | Mouse IgG1, κ |
| Clonality： | Monoclonal |
| Abbre： | CD49d |
| Swissprot： | P13612 | Links: https://www.uniprot.org/uniprot/P13612 |
| Cellular Localization： | Membrane |
| Concentration： | 5 μL/Test |
| Storage： | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| CloneNo： | 9F10 |
| Conjugation： | PE/Cyanine 5.5 |
| Background： | CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Form： | Liquid |
| Conjugation Information： | PE/Cyanine5.5 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 690 nm (e.g., a 690/50 nm bandpass filter). |
| Spectrum： | |
| Storage Buffer： | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Expiration Date： | 12个月 |
| Shipping： | 冰袋 |
| Host： | Mouse |
| Isotype Control： | PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21] | Links: /p-pe_cyanine5_5_mouse_igg1_isotype_control_mopc_21-e_ab_f09792i |
| Gene ID： | 3676 | Links: https://www.ncbi.nlm.nih.gov/gene/3676 |
| Alternate Names： | CD49 antigen-like family member D, CD49d, ITGA4, Integrin alpha-4, Integrin alpha-IV, VLA-4 subunit alpha |
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