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| 产品货号： | E-AB-F1199D |
|---|---|
| 英文名称： | PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] |
| 产品分类： | 流式抗体 |
| 文献（数量）： | 4 |
| 说明书（链接）： | https://789.bio/ea/y1ujL4 |
| Reactivity： | Mouse |
| Isotype： | Rat IgG1, κ |
| Clonality： | Monoclonal |
| Abbre： | IL-17A |
| Swissprot： | Q62386 | Links: https://www.uniprot.org/uniprot/Q62386 |
| Cellular Localization： | Secreted |
| Concentration： | 5 μL/Test |
| Storage： | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| CloneNo： | TC11-18H10.1 |
| Conjugation： | PE |
| Background： | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
| Leadtime： | 咨询 |
| Applications： | ICFCM |
| Form： | Liquid |
| Conjugation Information： | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
| Spectrum： | |
| Storage Buffer： | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Expiration Date： | 12个月 |
| Shipping： | 冰袋 |
| Host： | Rat |
| Isotype Control： | PE Rat IgG1, κ Isotype Control[HRPN] | Links: /p-pe_rat_igg1_isotype_control_hrpn-e_ab_f09822d |
| Gene ID： | 16171 | Links: https://www.ncbi.nlm.nih.gov/gene/16171 |
| Alternate Names： | CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, Interleukin-17A |
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