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| 产品货号： | E-AB-F1238D |
|---|---|
| 英文名称： | PE Anti-Mouse Foxp3 Antibody[3G3] |
| 产品分类： | 流式抗体 |
| 文献（数量）： | 9 |
| 说明书（链接）： | https://789.bio/ea/zTGaf1 |
| Reactivity： | Mouse |
| Isotype： | Mouse IgG1, κ |
| Clonality： | Monoclonal |
| Abbre： | Foxp3 |
| Swissprot： | Q99JB6 | Links: https://www.uniprot.org/uniprot/Q99JB6 |
| Cellular Localization： | Nucleus |
| Concentration： | 5 μL/Test |
| Storage： | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| CloneNo： | 3G3 |
| Conjugation： | PE |
| Background： | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in ‘scurfy’ mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. |
| Leadtime： | 咨询 |
| Applications： | ICFCM |
| Form： | Liquid |
| Conjugation Information： | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
| Spectrum： | |
| Storage Buffer： | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Expiration Date： | 12个月 |
| Shipping： | 冰袋 |
| Host： | Mouse |
| Isotype Control： | PE Mouse IgG1, κ Isotype Control[MOPC-21] | Links: /p-pe_mouse_igg1_isotype_control_mopc_21-e_ab_f09792d |
| Gene ID： | 50943,20371,317382 | Links: https://www.ncbi.nlm.nih.gov/gene/50943,20371,317382 |
| Alternate Names： | Forkhead box protein P3, Foxp3, IPEX, JM2 |
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