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| 产品货号： | E-AB-F1158M |
|---|---|
| 英文名称： | Elab Fluor® 647 Anti-Human CD196/CCR6 Antibody[G034E3] |
| 产品分类： | 流式抗体 |
| 说明书（链接）： | https://789.bio/ea/uHiH8G |
| Reactivity： | Human |
| Isotype： | Mouse IgG2b, κ |
| Clonality： | Monoclonal |
| Abbre： | CD196;CCR6 |
| Swissprot： | P51684 | Links: https://www.uniprot.org/uniprot/P51684 |
| Cellular Localization： | Membrane |
| Concentration： | 5 μL/Test |
| Storage： | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| CloneNo： | G034E3 |
| Conjugation： | Elab Fluor®647 |
| Background： | CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues. |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Form： | Liquid |
| Conjugation Information： | Elab Fluor®647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum： | |
| Storage Buffer： | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Expiration Date： | 12个月 |
| Shipping： | 冰袋 |
| Host： | Mouse |
| Isotype Control： | Elab Fluor®647 Mouse IgG2b, κ Isotype Control[MPC-11] | Links: /p-elab_fluor_647_mouse_igg2b_isotype_control_mpc_11-e_ab_f09812m |
| Gene ID： | 1235 | Links: https://www.ncbi.nlm.nih.gov/gene/1235 |
| Alternate Names： | CMKBR6GPR29STRL22, CKRL3, GPRCY4 |
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