All products
| 产品货号： | AN003420 |
|---|---|
| 英文名称： | AF/LE Purified Anti-Mouse CD3e Antibody[500A2] |
| 产品分类： | 流式纯抗 |
| 说明书（链接）： | https://789.bio/ea/8484C8 |
| Reactivity： | Mouse |
| Isotype： | Syrian Hamster IgG |
| Verified Samples： | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Dilution： | FCM 2 μg/mL(1×10^5-5×10^5 cells) |
| Clonality： | Monoclonal |
| Immunogen： | Recombinant Mouse CD3e protein |
| Abbre： | CD3e |
| Swissprot： | P22646 | Links: https://www.uniprot.org/uniprot/P22646 |
| Concentration： | ≥ 1 mg/mL |
| Storage： | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Purification Method： | >98%, Protein A/G purified |
| CloneNo： | 500A2 |
| Conjugation： | None (AF/LE) |
| Background： | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region |
| Leadtime： | 咨询 |
| Applications： | FCM |
| Storage Buffer： | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Expiration Date： | 12个月 |
| Shipping： | Order now, ship in 3 days |
| Host： | Syrian Hamster |
| Alternate Names： | T3E, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, Cd3e, T3, CD3epsilon |
评价
清除筛选目前还没有评价